2025 Big 12 Conference Leaders Rushing Defense - Games in August/September Only through 11/04/2025
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Texas Tech | 4 | 113 | 225 | 1.99 | 2 | 28.25 | 56.25 |
| 2 | BYU | 4 | 120 | 305 | 2.54 | 3 | 30.00 | 76.25 |
| 3 | Arizona State | 5 | 149 | 391 | 2.62 | 5 | 29.80 | 78.20 |
| 4 | Arizona | 4 | 131 | 399 | 3.05 | 7 | 32.75 | 99.75 |
| 5 | Cincinnati | 4 | 132 | 428 | 3.24 | 1 | 33.00 | 107.00 |
| 6 | Houston | 4 | 150 | 501 | 3.34 | 5 | 37.50 | 125.25 |
| 7 | TCU | 4 | 145 | 522 | 3.60 | 3 | 36.25 | 130.50 |
| 8 | Iowa State | 5 | 152 | 591 | 3.89 | 3 | 30.40 | 118.20 |
| 9 | UCF | 4 | 159 | 654 | 4.11 | 4 | 39.75 | 163.50 |
| 10 | Utah | 5 | 175 | 704 | 4.02 | 4 | 35.00 | 140.80 |
| 11 | Kansas | 5 | 182 | 747 | 4.10 | 6 | 36.40 | 149.40 |
| 12 | West Virginia | 5 | 207 | 765 | 3.70 | 4 | 41.40 | 153.00 |
| 13 | Oklahoma State | 4 | 157 | 852 | 5.43 | 7 | 39.25 | 213.00 |
| 14 | Baylor | 5 | 209 | 901 | 4.31 | 10 | 41.80 | 180.20 |
| 15 | Kansas State | 5 | 227 | 908 | 4.00 | 10 | 45.40 | 181.60 |
| 16 | Colorado | 5 | 207 | 986 | 4.76 | 7 | 41.40 | 197.20 |