2025 Conference USA Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 10/09/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Kennesaw State | 2 | 14 | 11 | 3 | 28 | 14.0 |
| 2 | Jacksonville State | 1 | 11 | 5 | 2 | 18 | 18.0 |
| 3 | Missouri State | 2 | 9 | 16 | 5 | 30 | 15.0 |
| 4 | Louisiana Tech | 1 | 7 | 2 | 3 | 12 | 12.0 |
| 5 | Delaware | 1 | 6 | 12 | 1 | 19 | 19.0 |
| 5 | FIU | 1 | 6 | 8 | 0 | 14 | 14.0 |
| 5 | Middle Tennessee State | 1 | 6 | 8 | 0 | 14 | 14.0 |
| 8 | UTEP | 1 | 3 | 7 | 3 | 13 | 13.0 |
| 9 | Sam Houston State | 1 | 2 | 4 | 1 | 7 | 7.0 |