2025 Conference USA Leaders First Downs - Games vs. FBS Power 5 Conference Teams Only through 12/13/2025
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Delaware | 2 | 14 | 22 | 2 | 38 | 19.0 |
| 1 | Kennesaw State | 2 | 14 | 11 | 3 | 28 | 14.0 |
| 3 | Louisiana Tech | 2 | 13 | 5 | 5 | 23 | 11.5 |
| 4 | Jacksonville State | 1 | 11 | 5 | 2 | 18 | 18.0 |
| 5 | Missouri State | 2 | 9 | 16 | 5 | 30 | 15.0 |
| 6 | New Mexico State | 1 | 7 | 14 | 3 | 24 | 24.0 |
| 7 | FIU | 1 | 6 | 8 | 0 | 14 | 14.0 |
| 7 | Middle Tennessee State | 1 | 6 | 8 | 0 | 14 | 14.0 |
| 9 | Sam Houston State | 2 | 5 | 8 | 2 | 15 | 7.5 |
| 10 | Western Kentucky | 1 | 3 | 7 | 4 | 14 | 14.0 |
| 10 | UTEP | 1 | 3 | 7 | 3 | 13 | 13.0 |