2025 Conference USA Leaders Opponent Penalties - Games vs. FBS Power 5 Conference Teams Only through 11/01/2025
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Missouri State | 2 | 17 | 175 | 8.5 | 87.5 |
| 2 | Kennesaw State | 2 | 12 | 115 | 6.0 | 57.5 |
| 3 | Jacksonville State | 1 | 9 | 80 | 9.0 | 80.0 |
| 3 | Louisiana Tech | 1 | 9 | 77 | 9.0 | 77.0 |
| 3 | Sam Houston State | 1 | 9 | 70 | 9.0 | 70.0 |
| 6 | UTEP | 1 | 7 | 78 | 7.0 | 78.0 |
| 7 | Delaware | 1 | 4 | 40 | 4.0 | 40.0 |
| 8 | FIU | 1 | 1 | 10 | 1.0 | 10.0 |
| 9 | Middle Tennessee State | 1 | 0 | 0 | 0.0 | 0.0 |