2025 Conference USA Leaders Sacks - Games in October Only through 10/08/2025
| Name | Team | Yr | Pos | G | Sacks | Sack Yards | Sacks/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Keegan Davis | FIU | SR | DL | 1 | 2.0 | 12 | 2.00 |
| 2 | Anthony Bynum | MTSU | SO | DE | 1 | 1.0 | 20 | 1.00 |
| 2 | Reggie Johnson | MTSU | JR | OLB | 1 | 1.0 | 9 | 1.00 |
| 2 | A'Khori Jones | Liberty | SR | S | 1 | 1.0 | 8 | 1.00 |
| 2 | Ezra Christensen | NMSU | SR | DL | 1 | 1.0 | 8 | 1.00 |
| 2 | Lantz Russell | UTEP | SR | S | 1 | 1.0 | 7 | 1.00 |
| 2 | Kenton Simmons | FIU | JR | DL | 1 | 1.0 | 6 | 1.00 |
| 2 | Bryce Dixon | Liberty | JR | DT | 1 | 1.0 | 6 | 1.00 |
| 2 | Joe Strickland | Liberty | SO | DL | 1 | 1.0 | 5 | 1.00 |
| 2 | Christofer Noble | MTSU | FR | S | 1 | 1.0 | 5 | 1.00 |
| 2 | Brandon Buckner | MTSU | SR | OLB | 1 | 1.0 | 4 | 1.00 |
| 2 | Thomas Anderson | MO State | SR | CB | 1 | 1.0 | 3 | 1.00 |
| 2 | Gavin Moul | Delaware | JR | LB | 1 | 1.0 | 2 | 1.00 |
| 2 | Darien Jackson | Sam Hou St | SO | DT | 1 | 1.0 | 2 | 1.00 |
| 2 | Tory Gethers | NMSU | JR | LB | 1 | 1.0 | 1 | 1.00 |
| 2 | Dylan Dixson | MO State | JR | NB | 1 | 1.0 | 1 | 1.00 |
Note: To qualify, player must have played in 75% of his team's games.