2022 Mid-American Conference Leaders Total Defense - Games in August/September Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 4 | 748 | 663 | 266 | 1411 | 5.30 | 352.8 |
| 2 | Ball State | 4 | 676 | 959 | 303 | 1635 | 5.40 | 408.8 |
| 3 | Western Michigan | 4 | 709 | 982 | 245 | 1691 | 6.90 | 422.8 |
| 4 | Buffalo | 4 | 726 | 1008 | 231 | 1734 | 7.51 | 433.5 |
| 5 | Miami (Ohio) | 4 | 334 | 1080 | 261 | 1414 | 5.42 | 353.5 |
| 6 | Akron | 4 | 844 | 1090 | 290 | 1934 | 6.67 | 483.5 |
| 7 | Central Michigan | 4 | 477 | 1132 | 298 | 1609 | 5.40 | 402.3 |
| 8 | Eastern Michigan | 4 | 661 | 1140 | 286 | 1801 | 6.30 | 450.3 |
| 9 | Northern Illinois | 4 | 548 | 1156 | 262 | 1704 | 6.50 | 426.0 |
| 9 | Kent State | 4 | 635 | 1156 | 283 | 1791 | 6.33 | 447.8 |
| 11 | Bowling Green | 4 | 623 | 1457 | 316 | 2080 | 6.58 | 520.0 |
| 12 | Ohio | 4 | 648 | 1505 | 289 | 2153 | 7.45 | 538.3 |