2022 American Athletic Conference Leaders Scoring Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | East Carolina University | 1 | 3 | 0 | 3 | 0 | 0 | 21 | 21.0 |
| 2 | Temple University | 2 | 4 | 6 | 4 | 0 | 0 | 46 | 23.0 |
| 3 | The University of Tulsa | 1 | 5 | 0 | 5 | 0 | 0 | 35 | 35.0 |
| 4 | University of Central Florida | 3 | 6 | 6 | 6 | 0 | 0 | 60 | 20.0 |
| 5 | Tulane University | 2 | 7 | 2 | 7 | 0 | 0 | 55 | 27.5 |
| 5 | University of Memphis | 1 | 7 | 0 | 7 | 0 | 0 | 49 | 49.0 |
| 7 | University of South Florida | 2 | 9 | 3 | 9 | 0 | 0 | 72 | 36.0 |
| 8 | University of Cincinnati | 3 | 10 | 3 | 10 | 0 | 0 | 79 | 26.3 |
| 8 | Southern Methodist University | 2 | 10 | 2 | 10 | 0 | 0 | 76 | 38.0 |
| 8 | University of Houston | 2 | 10 | 4 | 9 | 0 | 0 | 81 | 40.5 |