2022 American Athletic Conference Leaders Rushing Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Memphis | 1 | 34 | 97 | 2.85 | 2 | 34.00 | 97.00 |
| 2 | East Carolina | 1 | 32 | 133 | 4.16 | 1 | 32.00 | 133.00 |
| 3 | Tulsa | 1 | 51 | 308 | 6.04 | 3 | 51.00 | 308.00 |
| 4 | Temple | 2 | 76 | 314 | 4.13 | 1 | 38.00 | 157.00 |
| 5 | Tulane | 2 | 74 | 318 | 4.30 | 1 | 37.00 | 159.00 |
| 6 | Houston | 2 | 87 | 398 | 4.57 | 5 | 43.50 | 199.00 |
| 7 | SMU | 2 | 73 | 416 | 5.70 | 5 | 36.50 | 208.00 |
| 8 | USF | 2 | 76 | 500 | 6.58 | 7 | 38.00 | 250.00 |
| 9 | UCF | 3 | 116 | 531 | 4.58 | 5 | 38.67 | 177.00 |
| 10 | Cincinnati | 3 | 132 | 579 | 4.39 | 4 | 44.00 | 193.00 |