2022 American Athletic Conference Leaders Total Defense - Games in August/September Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 3 | 207 | 871 | 190 | 1078 | 5.67 | 359.3 |
| 2 | East Carolina | 4 | 442 | 938 | 257 | 1380 | 5.37 | 345.0 |
| 3 | Cincinnati | 4 | 501 | 730 | 308 | 1231 | 4.00 | 307.8 |
| 4 | Memphis | 4 | 509 | 1195 | 298 | 1704 | 5.72 | 426.0 |
| 5 | Temple | 4 | 520 | 550 | 251 | 1070 | 4.26 | 267.5 |
| 6 | UCF | 4 | 577 | 679 | 252 | 1256 | 4.98 | 314.0 |
| 7 | Houston | 5 | 676 | 1368 | 361 | 2044 | 5.66 | 408.8 |
| 8 | Tulane | 5 | 680 | 618 | 321 | 1298 | 4.04 | 259.6 |
| 9 | SMU | 4 | 722 | 878 | 283 | 1600 | 5.65 | 400.0 |
| 10 | Tulsa | 4 | 785 | 756 | 277 | 1541 | 5.56 | 385.3 |
| 11 | South Florida | 4 | 982 | 882 | 270 | 1864 | 6.90 | 466.0 |