2022 American Athletic Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 11 | 1001 | 2733 | 648 | 3734 | 5.76 | 339.5 |
| 2 | Memphis | 11 | 1304 | 2529 | 745 | 3833 | 5.14 | 348.5 |
| 3 | East Carolina | 12 | 1421 | 3456 | 795 | 4877 | 6.13 | 406.4 |
| 4 | Cincinnati | 12 | 1771 | 2207 | 875 | 3978 | 4.55 | 331.5 |
| 5 | Houston | 12 | 1775 | 3433 | 874 | 5208 | 5.96 | 434.0 |
| 6 | UCF | 12 | 1803 | 2482 | 812 | 4285 | 5.28 | 357.1 |
| 7 | Tulane | 12 | 1814 | 2301 | 852 | 4115 | 4.83 | 342.9 |
| 8 | Tulsa | 11 | 2138 | 2351 | 774 | 4489 | 5.80 | 408.1 |
| 9 | SMU | 11 | 2146 | 2524 | 813 | 4670 | 5.74 | 424.5 |
| 10 | Temple | 12 | 2311 | 2383 | 832 | 4694 | 5.64 | 391.2 |
| 11 | South Florida | 11 | 2582 | 3055 | 748 | 5637 | 7.54 | 512.5 |