2022 Atlantic Coast Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia | 8 | 1273 | 1649 | 581 | 2922 | 5.03 | 365.3 |
| 2 | Virginia Tech | 8 | 1250 | 2053 | 580 | 3303 | 5.69 | 412.9 |
| 3 | Miami (Florida) | 9 | 1489 | 1933 | 594 | 3422 | 5.76 | 380.2 |
| 4 | Boston College | 9 | 1532 | 1916 | 613 | 3448 | 5.62 | 383.1 |
| 5 | Louisville | 9 | 1290 | 2185 | 609 | 3475 | 5.71 | 386.1 |
| 6 | North Carolina State | 10 | 1036 | 2521 | 674 | 3557 | 5.28 | 355.7 |
| 7 | Clemson | 11 | 1044 | 2589 | 729 | 3633 | 4.98 | 330.3 |
| 8 | Syracuse | 10 | 1504 | 2163 | 713 | 3667 | 5.14 | 366.7 |
| 9 | Florida State | 11 | 1808 | 1920 | 745 | 3728 | 5.00 | 338.9 |
| 10 | Pittsburgh | 11 | 1161 | 2662 | 734 | 3823 | 5.21 | 347.5 |
| 11 | Duke | 10 | 1162 | 2896 | 699 | 4058 | 5.81 | 405.8 |
| 12 | Georgia Tech | 10 | 1867 | 2229 | 718 | 4096 | 5.70 | 409.6 |
| 13 | North Carolina | 10 | 1447 | 2683 | 687 | 4130 | 6.01 | 413.0 |
| 14 | Wake Forest | 10 | 1281 | 2912 | 711 | 4193 | 5.90 | 419.3 |