2022 Atlantic Coast Conference Leaders Total Defense - Games in August/September Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia Tech | 4 | 344 | 680 | 248 | 1024 | 4.13 | 256.0 |
| 2 | North Carolina State | 4 | 327 | 719 | 246 | 1046 | 4.25 | 261.5 |
| 3 | Florida State | 4 | 579 | 663 | 253 | 1242 | 4.91 | 310.5 |
| 4 | Pittsburgh | 4 | 394 | 892 | 250 | 1286 | 5.14 | 321.5 |
| 5 | Syracuse | 4 | 444 | 864 | 244 | 1308 | 5.36 | 327.0 |
| 6 | Miami (Florida) | 4 | 340 | 1004 | 219 | 1344 | 6.14 | 336.0 |
| 7 | Clemson | 4 | 314 | 1071 | 271 | 1385 | 5.11 | 346.3 |
| 8 | Virginia | 4 | 532 | 868 | 279 | 1400 | 5.02 | 350.0 |
| 9 | Louisville | 4 | 653 | 748 | 265 | 1401 | 5.29 | 350.3 |
| 10 | Wake Forest | 4 | 559 | 947 | 291 | 1506 | 5.18 | 376.5 |
| 11 | Boston College | 4 | 625 | 889 | 272 | 1514 | 5.57 | 378.5 |
| 12 | Duke | 4 | 562 | 1010 | 277 | 1572 | 5.68 | 393.0 |
| 13 | Georgia Tech | 4 | 838 | 810 | 307 | 1648 | 5.37 | 412.0 |
| 14 | North Carolina | 4 | 866 | 1115 | 308 | 1981 | 6.43 | 495.3 |