2022 Conference USA Leaders Total Defense - Games in October Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 3 | 569 | 747 | 219 | 1316 | 6.01 | 438.7 |
| 2 | Florida Atlantic | 4 | 878 | 748 | 266 | 1626 | 6.11 | 406.5 |
| 3 | UAB | 5 | 744 | 839 | 312 | 1583 | 5.07 | 316.6 |
| 4 | Rice | 4 | 690 | 868 | 283 | 1558 | 5.51 | 389.5 |
| 5 | UTSA | 3 | 267 | 884 | 200 | 1151 | 5.76 | 383.7 |
| 6 | Charlotte | 4 | 830 | 928 | 275 | 1758 | 6.39 | 439.5 |
| 7 | UTEP | 4 | 492 | 1042 | 245 | 1534 | 6.26 | 383.5 |
| 8 | Louisiana Tech | 4 | 992 | 1045 | 303 | 2037 | 6.72 | 509.3 |
| 9 | Florida International | 5 | 751 | 1082 | 351 | 1833 | 5.22 | 366.6 |
| 10 | Western Kentucky | 5 | 838 | 1222 | 350 | 2060 | 5.89 | 412.0 |
| 11 | North Texas | 4 | 620 | 1277 | 327 | 1897 | 5.80 | 474.3 |