2021 Colorado Buffaloes Total Defense Split Stats through 01/10/2022
| Split | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G |
|---|---|---|---|---|---|---|---|
| All Games | 12 | 2142 | 2908 | 834 | 5050 | 6.06 | 420.8 |
| at Home | 6 | 899 | 1472 | 429 | 2371 | 5.53 | 395.2 |
| on Road/Neutral Site | 6 | 1243 | 1436 | 405 | 2679 | 6.61 | 446.5 |
| in Wins | 4 | 405 | 1032 | 295 | 1437 | 4.87 | 359.3 |
| in Losses | 8 | 1737 | 1876 | 539 | 3613 | 6.70 | 451.6 |
| vs. Conference | 9 | 1748 | 2317 | 635 | 4065 | 6.40 | 451.7 |
| vs. Non-Conference | 3 | 394 | 591 | 199 | 985 | 4.95 | 328.3 |
| vs. Ranked (AP) | 2 | 521 | 491 | 140 | 1012 | 7.23 | 506.0 |
| vs. Unranked (AP) | 10 | 1621 | 2417 | 694 | 4038 | 5.82 | 403.8 |
| vs. FBS (I-A) | 11 | 2122 | 2672 | 774 | 4794 | 6.19 | 435.8 |
| vs. FCS (I-AA) | 1 | 20 | 236 | 60 | 256 | 4.27 | 256.0 |
| vs. FBS Winning | 7 | 1526 | 1630 | 486 | 3156 | 6.49 | 450.9 |
| vs. FBS Non-Winning | 4 | 596 | 1042 | 288 | 1638 | 5.69 | 409.5 |
| vs. FBS Power 5 | 11 | 2122 | 2672 | 774 | 4794 | 6.19 | 435.8 |
| vs. FBS non-Power 5 | 0 | 0 | 0 | 0 | 0 | - | - |
| in August/September | 4 | 561 | 863 | 258 | 1424 | 5.52 | 356.0 |
| in October | 4 | 814 | 966 | 276 | 1780 | 6.45 | 445.0 |
| in November | 4 | 767 | 1079 | 300 | 1846 | 6.15 | 461.5 |
| in December/January | 0 | 0 | 0 | 0 | 0 | - | - |