2021 National Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 13 | 21 | 59 | 80 | 6.15 |
| 2 | Hawaii | 11 | 14 | 51 | 65 | 5.91 |
| 3 | Tennessee | 8 | 11 | 35 | 46 | 5.75 |
| 3 | Penn State | 8 | 10 | 36 | 46 | 5.75 |
| 5 | Middle Tennessee State | 13 | 17 | 57 | 74 | 5.69 |
| 6 | Iowa | 12 | 22 | 46 | 68 | 5.67 |
| 7 | Florida State | 8 | 10 | 35 | 45 | 5.63 |
| 8 | East Carolina | 10 | 13 | 43 | 56 | 5.60 |
| 9 | UCF | 12 | 11 | 56 | 67 | 5.58 |
| 10 | California | 11 | 13 | 47 | 60 | 5.45 |
| 11 | Utah | 9 | 7 | 42 | 49 | 5.44 |
| 12 | Georgia | 9 | 11 | 37 | 48 | 5.33 |
| 12 | Ohio State | 9 | 11 | 37 | 48 | 5.33 |
| 14 | Michigan State | 10 | 7 | 46 | 53 | 5.30 |
| 14 | San Jose State | 10 | 5 | 48 | 53 | 5.30 |
| 16 | Toledo | 12 | 7 | 56 | 63 | 5.25 |
| 17 | Texas A&M | 9 | 9 | 38 | 47 | 5.22 |
| 18 | Oregon State | 10 | 13 | 39 | 52 | 5.20 |
| 19 | San Diego State | 12 | 15 | 47 | 62 | 5.17 |
| 19 | Florida Atlantic | 12 | 13 | 49 | 62 | 5.17 |
| 21 | Nevada | 12 | 14 | 46 | 60 | 5.00 |
| 21 | Memphis | 11 | 7 | 48 | 55 | 5.00 |
| 21 | Rice | 10 | 13 | 37 | 50 | 5.00 |
| 21 | NC State | 10 | 11 | 39 | 50 | 5.00 |
| 21 | Washington State | 9 | 14 | 31 | 45 | 5.00 |
| 21 | Clemson | 9 | 10 | 35 | 45 | 5.00 |
| 27 | Cincinnati | 11 | 15 | 39 | 54 | 4.91 |
| 28 | Arkansas | 10 | 13 | 36 | 49 | 4.90 |
| 29 | Vanderbilt | 9 | 10 | 34 | 44 | 4.89 |
| 29 | Tulsa | 9 | 7 | 37 | 44 | 4.89 |
| 31 | UAB | 11 | 9 | 44 | 53 | 4.82 |
| 32 | Arizona State | 11 | 12 | 40 | 52 | 4.73 |
| 33 | South Carolina | 10 | 11 | 36 | 47 | 4.70 |
| 33 | Michigan | 10 | 5 | 42 | 47 | 4.70 |
| 35 | UTEP | 13 | 8 | 53 | 61 | 4.69 |
| 35 | Central Michigan | 13 | 5 | 56 | 61 | 4.69 |
| 37 | Georgia State | 12 | 10 | 46 | 56 | 4.67 |
| 37 | Texas Tech | 9 | 6 | 36 | 42 | 4.67 |
| 39 | Fresno State | 11 | 9 | 42 | 51 | 4.64 |
| 39 | Illinois | 11 | 8 | 43 | 51 | 4.64 |
| 41 | Appalachian State | 12 | 14 | 41 | 55 | 4.58 |
| 42 | Maryland | 9 | 5 | 36 | 41 | 4.56 |
| 43 | Kent State | 13 | 16 | 43 | 59 | 4.54 |
| 44 | UCLA | 10 | 10 | 35 | 45 | 4.50 |
| 44 | New Mexico | 10 | 9 | 36 | 45 | 4.50 |
| 44 | Ole Miss | 10 | 8 | 37 | 45 | 4.50 |
| 44 | Louisville | 8 | 9 | 27 | 36 | 4.50 |
| 48 | Arkansas State | 11 | 10 | 39 | 49 | 4.45 |
| 49 | Purdue | 9 | 8 | 32 | 40 | 4.44 |
| 50 | Duke | 10 | 8 | 36 | 44 | 4.40 |
| 51 | Louisiana | 14 | 10 | 51 | 61 | 4.36 |
| 52 | Rutgers | 9 | 6 | 33 | 39 | 4.33 |
| 53 | Alabama | 10 | 13 | 30 | 43 | 4.30 |
| 54 | Notre Dame | 11 | 15 | 32 | 47 | 4.27 |
| 55 | Old Dominion | 12 | 7 | 44 | 51 | 4.25 |
| 56 | Houston | 13 | 14 | 41 | 55 | 4.23 |
| 57 | BYU | 10 | 11 | 31 | 42 | 4.20 |
| 58 | Virginia | 8 | 5 | 28 | 33 | 4.13 |
| 59 | Baylor | 9 | 7 | 30 | 37 | 4.11 |
| 60 | Wisconsin | 10 | 15 | 26 | 41 | 4.10 |
| 60 | Oregon | 10 | 14 | 27 | 41 | 4.10 |
| 60 | SMU | 10 | 10 | 31 | 41 | 4.10 |
| 63 | Liberty | 11 | 9 | 36 | 45 | 4.09 |
| 64 | UTSA | 13 | 12 | 41 | 53 | 4.08 |
| 65 | Eastern Michigan | 13 | 8 | 44 | 52 | 4.00 |
| 65 | Miami (OH) | 12 | 7 | 41 | 48 | 4.00 |
| 65 | Wake Forest | 11 | 12 | 32 | 44 | 4.00 |
| 65 | Minnesota | 11 | 7 | 37 | 44 | 4.00 |
| 65 | Louisiana-Monroe | 10 | 10 | 30 | 40 | 4.00 |
| 65 | Connecticut | 10 | 8 | 32 | 40 | 4.00 |
| 65 | LSU | 9 | 8 | 28 | 36 | 4.00 |
| 72 | Southern Miss | 11 | 10 | 33 | 43 | 3.91 |
| 72 | Virginia Tech | 11 | 8 | 35 | 43 | 3.91 |
| 74 | Washington | 10 | 9 | 30 | 39 | 3.90 |
| 75 | Georgia Southern | 9 | 5 | 30 | 35 | 3.89 |
| 76 | Iowa State | 8 | 9 | 22 | 31 | 3.88 |
| 77 | Utah State | 12 | 12 | 34 | 46 | 3.83 |
| 77 | Marshall | 12 | 10 | 36 | 46 | 3.83 |
| 77 | Army | 12 | 10 | 36 | 46 | 3.83 |
| 80 | South Alabama | 11 | 15 | 27 | 42 | 3.82 |
| 81 | Kansas State | 10 | 10 | 28 | 38 | 3.80 |
| 82 | Northwestern | 9 | 6 | 28 | 34 | 3.78 |
| 83 | Coastal Carolina | 13 | 6 | 43 | 49 | 3.77 |
| 84 | Boise State | 8 | 10 | 20 | 30 | 3.75 |
| 84 | Auburn | 8 | 5 | 25 | 30 | 3.75 |
| 86 | Pittsburgh | 11 | 9 | 32 | 41 | 3.73 |
| 86 | Kentucky | 11 | 6 | 35 | 41 | 3.73 |
| 88 | Texas State | 10 | 3 | 34 | 37 | 3.70 |
| 89 | Boston College | 9 | 9 | 24 | 33 | 3.67 |
| 89 | Stanford | 9 | 4 | 29 | 33 | 3.67 |
| 91 | USF | 8 | 8 | 21 | 29 | 3.63 |
| 92 | Colorado | 10 | 7 | 29 | 36 | 3.60 |
| 93 | Bowling Green | 12 | 12 | 31 | 43 | 3.58 |
| 94 | Troy | 11 | 16 | 23 | 39 | 3.55 |
| 94 | Air Force | 11 | 7 | 32 | 39 | 3.55 |
| 96 | Florida | 10 | 6 | 29 | 35 | 3.50 |
| 97 | TCU | 9 | 8 | 23 | 31 | 3.44 |
| 98 | Indiana | 7 | 1 | 23 | 24 | 3.43 |
| 99 | Wyoming | 12 | 9 | 32 | 41 | 3.42 |
| 100 | Missouri | 10 | 9 | 25 | 34 | 3.40 |
| 101 | Western Michigan | 11 | 3 | 34 | 37 | 3.36 |
| 102 | Ball State | 13 | 15 | 28 | 43 | 3.31 |
| 103 | Oklahoma State | 10 | 8 | 25 | 33 | 3.30 |
| 104 | Nebraska | 7 | 6 | 17 | 23 | 3.29 |
| 105 | Louisiana Tech | 11 | 9 | 27 | 36 | 3.27 |
| 106 | Charlotte | 12 | 8 | 31 | 39 | 3.25 |
| 106 | Tulane | 8 | 7 | 19 | 26 | 3.25 |
| 106 | Miami (FL) | 8 | 6 | 20 | 26 | 3.25 |
| 106 | Arizona | 8 | 4 | 22 | 26 | 3.25 |
| 110 | Colorado State | 10 | 4 | 28 | 32 | 3.20 |
| 111 | New Mexico State | 8 | 7 | 18 | 25 | 3.13 |
| 112 | North Carolina | 9 | 8 | 20 | 28 | 3.11 |
| 112 | Navy | 9 | 6 | 22 | 28 | 3.11 |
| 114 | Massachusetts | 11 | 2 | 32 | 34 | 3.09 |
| 115 | Northern Illinois | 13 | 3 | 36 | 39 | 3.00 |
| 115 | Temple | 10 | 6 | 24 | 30 | 3.00 |
| 115 | Georgia Tech | 8 | 3 | 21 | 24 | 3.00 |
| 118 | Ohio | 11 | 5 | 27 | 32 | 2.91 |
| 119 | Mississippi State | 8 | 5 | 18 | 23 | 2.88 |
| 120 | Buffalo | 12 | 3 | 31 | 34 | 2.83 |
| 121 | USC | 9 | 11 | 14 | 25 | 2.78 |
| 122 | North Texas | 13 | 6 | 30 | 36 | 2.77 |
| 123 | Texas | 7 | 2 | 17 | 19 | 2.71 |
| 124 | FIU | 12 | 3 | 29 | 32 | 2.67 |
| 124 | Kansas | 9 | 6 | 18 | 24 | 2.67 |
| 126 | Syracuse | 8 | 2 | 19 | 21 | 2.63 |
| 127 | West Virginia | 10 | 7 | 19 | 26 | 2.60 |
| 128 | Oklahoma | 10 | 7 | 16 | 23 | 2.30 |
| 129 | UNLV | 10 | 7 | 14 | 21 | 2.10 |
| 130 | Akron | 11 | 5 | 17 | 22 | 2.00 |