2021 FBS Independents Leaders Passes Defended - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Notre Dame | 10 | 15 | 26 | 41 | 4.10 |
| 2 | BYU | 7 | 8 | 30 | 38 | 5.43 |
| 3 | Connecticut | 3 | 2 | 10 | 12 | 4.00 |
| 4 | New Mexico State | 2 | 1 | 6 | 7 | 3.50 |
| 5 | Liberty | 2 | 0 | 5 | 5 | 2.50 |
| 5 | Massachusetts | 3 | 0 | 5 | 5 | 1.67 |
| 7 | Army | 3 | 0 | 4 | 4 | 1.33 |