2021 FBS Independents Leaders Passes Defended - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | BYU | 3 | 4 | 16 | 20 | 6.67 |
| 2 | New Mexico State | 4 | 3 | 11 | 14 | 3.50 |
| 3 | Connecticut | 2 | 2 | 5 | 7 | 3.50 |
| 4 | Liberty | 2 | 0 | 5 | 5 | 2.50 |
| 5 | Massachusetts | 1 | 0 | 4 | 4 | 4.00 |
| 5 | Notre Dame | 2 | 0 | 4 | 4 | 2.00 |