2021 Independent Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Liberty | 2 | 272 | 490 | 120 | 762 | 6.35 | 381.0 |
| 2 | BYU | 3 | 527 | 692 | 208 | 1219 | 5.86 | 406.3 |
| 3 | Connecticut | 2 | 278 | 670 | 165 | 948 | 5.75 | 474.0 |
| 4 | Notre Dame | 2 | 327 | 668 | 157 | 995 | 6.34 | 497.5 |
| 5 | New Mexico State | 4 | 856 | 1234 | 274 | 2090 | 7.63 | 522.5 |
| 6 | Massachusetts | 1 | 223 | 375 | 86 | 598 | 6.95 | 598.0 |
| 7 | Army | 1 | 180 | 458 | 52 | 638 | 12.27 | 638.0 |