2021 Southeastern Conference Leaders Total Defense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Kentucky | 2 | 339 | 461 | 107 | 800 | 7.48 | 400.0 |
| 2 | Florida | 3 | 421 | 488 | 162 | 909 | 5.61 | 303.0 |
| 3 | Missouri | 3 | 672 | 778 | 186 | 1450 | 7.80 | 483.3 |
| 4 | South Carolina | 3 | 679 | 508 | 194 | 1187 | 6.12 | 395.7 |
| 5 | Vanderbilt | 3 | 618 | 799 | 199 | 1417 | 7.12 | 472.3 |
| 6 | Arkansas | 3 | 709 | 918 | 213 | 1627 | 7.64 | 542.3 |
| 7 | Mississippi | 3 | 839 | 607 | 227 | 1446 | 6.37 | 482.0 |
| 8 | Texas A&M | 3 | 607 | 862 | 243 | 1469 | 6.05 | 489.7 |
| 9 | LSU | 4 | 742 | 794 | 265 | 1536 | 5.80 | 384.0 |
| 10 | Alabama | 5 | 511 | 1279 | 328 | 1790 | 5.46 | 358.0 |
| 11 | Mississippi State | 5 | 651 | 1226 | 341 | 1877 | 5.50 | 375.4 |
| 12 | Georgia | 6 | 364 | 1470 | 392 | 1834 | 4.68 | 305.7 |
| 13 | Auburn | 5 | 776 | 1366 | 396 | 2142 | 5.41 | 428.4 |
| 14 | Tennessee | 5 | 1077 | 1503 | 444 | 2580 | 5.81 | 516.0 |