2021 Pac-12 Conference Leaders Total Defense - Games in August/September Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Arizona State | 4 | 493 | 497 | 236 | 990 | 4.19 | 247.5 |
| 2 | Arizona | 4 | 734 | 688 | 252 | 1422 | 5.64 | 355.5 |
| 2 | USC | 4 | 629 | 935 | 252 | 1564 | 6.21 | 391.0 |
| 4 | Colorado | 4 | 561 | 863 | 258 | 1424 | 5.52 | 356.0 |
| 5 | Utah | 4 | 562 | 654 | 278 | 1216 | 4.37 | 304.0 |
| 6 | Washington | 4 | 669 | 688 | 279 | 1357 | 4.86 | 339.3 |
| 7 | Oregon State | 4 | 357 | 1118 | 284 | 1475 | 5.19 | 368.8 |
| 8 | Stanford | 4 | 836 | 769 | 285 | 1605 | 5.63 | 401.3 |
| 8 | California | 4 | 483 | 1188 | 285 | 1671 | 5.86 | 417.8 |
| 10 | Washington State | 4 | 591 | 1073 | 288 | 1664 | 5.78 | 416.0 |
| 11 | UCLA | 4 | 255 | 1321 | 290 | 1576 | 5.43 | 394.0 |
| 12 | Oregon | 4 | 547 | 1146 | 309 | 1693 | 5.48 | 423.3 |