2021 Pac-12 Conference Leaders Total Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Arizona | 8 | 1378 | 1391 | 495 | 2769 | 5.59 | 346.1 |
| 2 | Utah | 9 | 1023 | 1968 | 595 | 2991 | 5.03 | 332.3 |
| 3 | Washington | 10 | 1656 | 1573 | 659 | 3229 | 4.90 | 322.9 |
| 4 | Washington State | 9 | 1108 | 2180 | 613 | 3288 | 5.36 | 365.3 |
| 5 | Arizona State | 11 | 1357 | 2069 | 717 | 3426 | 4.78 | 311.5 |
| 6 | Oregon | 10 | 1156 | 2306 | 702 | 3462 | 4.93 | 346.2 |
| 7 | USC | 9 | 1466 | 2107 | 559 | 3573 | 6.39 | 397.0 |
| 8 | Oregon State | 10 | 1338 | 2351 | 662 | 3689 | 5.57 | 368.9 |
| 9 | UCLA | 10 | 1080 | 2647 | 708 | 3727 | 5.26 | 372.7 |
| 10 | Stanford | 9 | 1990 | 1912 | 615 | 3902 | 6.34 | 433.6 |
| 11 | California | 11 | 1431 | 2510 | 766 | 3941 | 5.14 | 358.3 |
| 12 | Colorado | 10 | 1621 | 2417 | 694 | 4038 | 5.82 | 403.8 |