2021 Mid-American Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Toledo | 12 | 7 | 57 | 64 | 5.33 |
| 2 | Central Michigan | 9 | 4 | 46 | 50 | 5.56 |
| 3 | Eastern Michigan | 11 | 6 | 38 | 44 | 4.00 |
| 4 | Kent State | 10 | 7 | 33 | 40 | 4.00 |
| 5 | Miami (Ohio) | 11 | 9 | 31 | 40 | 3.64 |
| 6 | Western Michigan | 10 | 2 | 30 | 32 | 3.20 |
| 7 | Buffalo | 10 | 3 | 29 | 32 | 3.20 |
| 7 | Northern Illinois | 11 | 3 | 29 | 32 | 2.91 |
| 9 | Ohio | 9 | 6 | 22 | 28 | 3.11 |
| 10 | Ball State | 11 | 14 | 21 | 35 | 3.18 |
| 11 | Bowling Green | 9 | 8 | 20 | 28 | 3.11 |
| 12 | Akron | 9 | 5 | 16 | 21 | 2.33 |