2021 Mid-American Conference Leaders Passes Defended - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Toledo | 12 | 7 | 56 | 63 | 5.25 |
| 1 | Central Michigan | 13 | 5 | 56 | 61 | 4.69 |
| 3 | Eastern Michigan | 13 | 8 | 44 | 52 | 4.00 |
| 4 | Kent State | 13 | 16 | 43 | 59 | 4.54 |
| 5 | Miami (Ohio) | 12 | 7 | 41 | 48 | 4.00 |
| 6 | Northern Illinois | 13 | 3 | 36 | 39 | 3.00 |
| 7 | Western Michigan | 11 | 3 | 34 | 37 | 3.36 |
| 8 | Bowling Green | 12 | 12 | 31 | 43 | 3.58 |
| 8 | Buffalo | 12 | 3 | 31 | 34 | 2.83 |
| 10 | Ball State | 13 | 15 | 28 | 43 | 3.31 |
| 11 | Ohio | 11 | 5 | 27 | 32 | 2.91 |
| 12 | Akron | 11 | 5 | 17 | 22 | 2.00 |