2021 Mid-American Conference Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 3 | 377 | 738 | 229 | 1115 | 4.87 | 371.7 |
| 2 | Kent State | 3 | 456 | 603 | 219 | 1059 | 4.84 | 353.0 |
| 3 | Western Michigan | 2 | 286 | 548 | 154 | 834 | 5.42 | 417.0 |
| 4 | Ohio | 2 | 313 | 381 | 126 | 694 | 5.51 | 347.0 |
| 5 | Northern Illinois | 2 | 326 | 182 | 112 | 508 | 4.54 | 254.0 |
| 6 | Akron | 2 | 73 | 344 | 137 | 417 | 3.04 | 208.5 |
| 7 | Bowling Green | 2 | 54 | 357 | 122 | 411 | 3.37 | 205.5 |
| 8 | Buffalo | 1 | 135 | 224 | 83 | 359 | 4.33 | 359.0 |
| 9 | Miami (Ohio) | 1 | 104 | 237 | 61 | 341 | 5.59 | 341.0 |
| 10 | Ball State | 1 | 69 | 226 | 71 | 295 | 4.15 | 295.0 |
| 11 | Eastern Michigan | 1 | 16 | 76 | 38 | 92 | 2.42 | 92.0 |