2021 Mid-American Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 1 | 124 | 229 | 63 | 353 | 5.60 | 353.0 |
| 2 | Western Michigan | 2 | 286 | 548 | 154 | 834 | 5.42 | 417.0 |
| 3 | Ohio | 1 | 112 | 138 | 55 | 250 | 4.55 | 250.0 |
| 4 | Kent State | 1 | 80 | 185 | 64 | 265 | 4.14 | 265.0 |
| 5 | Northern Illinois | 1 | 161 | 46 | 53 | 207 | 3.91 | 207.0 |
| 6 | Miami (Ohio) | 1 | 169 | 109 | 73 | 278 | 3.81 | 278.0 |
| 7 | Akron | 1 | 76 | 153 | 74 | 229 | 3.09 | 229.0 |