2021 Mid-American Conference Leaders Passes Defended - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Central Michigan | 6 | 3 | 34 | 37 | 6.17 |
| 2 | Toledo | 6 | 3 | 31 | 34 | 5.67 |
| 3 | Miami (Ohio) | 7 | 6 | 20 | 26 | 3.71 |
| 4 | Bowling Green | 5 | 7 | 14 | 21 | 4.20 |
| 4 | Buffalo | 7 | 2 | 19 | 21 | 3.00 |
| 6 | Northern Illinois | 6 | 2 | 17 | 19 | 3.17 |
| 7 | Kent State | 4 | 4 | 13 | 17 | 4.25 |
| 8 | Eastern Michigan | 5 | 2 | 14 | 16 | 3.20 |
| 8 | Western Michigan | 5 | 1 | 15 | 16 | 3.20 |
| 10 | Akron | 7 | 4 | 10 | 14 | 2.00 |
| 11 | Ohio | 6 | 1 | 10 | 11 | 1.83 |
| 12 | Ball State | 2 | 4 | 6 | 10 | 5.00 |