2021 Mid-American Conference Leaders Scoring Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 9 | 28 | 12 | 21 | 3 | 0 | 231 | 25.7 |
| 2 | Miami (Ohio) | 11 | 34 | 8 | 32 | 1 | 0 | 262 | 23.8 |
| 3 | Ohio | 9 | 33 | 14 | 28 | 1 | 1 | 272 | 30.2 |
| 4 | Toledo | 12 | 28 | 26 | 25 | 1 | 0 | 273 | 22.8 |
| 5 | Western Michigan | 10 | 34 | 14 | 31 | 1 | 0 | 279 | 27.9 |
| 6 | Ball State | 11 | 36 | 16 | 32 | 2 | 2 | 304 | 27.6 |
| 7 | Bowling Green | 9 | 40 | 11 | 37 | 0 | 0 | 310 | 34.4 |
| 8 | Buffalo | 10 | 42 | 10 | 40 | 0 | 1 | 324 | 32.4 |
| 9 | Eastern Michigan | 11 | 44 | 12 | 39 | 1 | 0 | 341 | 31.0 |
| 9 | Akron | 9 | 44 | 11 | 42 | 1 | 0 | 341 | 37.9 |
| 11 | Northern Illinois | 11 | 47 | 15 | 41 | 2 | 1 | 374 | 34.0 |
| 12 | Kent State | 10 | 50 | 15 | 43 | 1 | 0 | 390 | 39.0 |