2021 Mid-American Conference Leaders Opponent First Downs - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Buffalo | 1 | 9 | 7 | 3 | 19 | 19.0 |
| 2 | Miami (Ohio) | 1 | 11 | 6 | 2 | 19 | 19.0 |
| 3 | Eastern Michigan | 1 | 14 | 10 | 2 | 26 | 26.0 |
| 4 | Ball State | 1 | 16 | 15 | 1 | 32 | 32.0 |
| 5 | Central Michigan | 3 | 18 | 33 | 9 | 60 | 20.0 |
| 6 | Western Michigan | 2 | 22 | 20 | 5 | 47 | 23.5 |
| 7 | Ohio | 2 | 29 | 12 | 2 | 43 | 21.5 |
| 8 | Akron | 2 | 30 | 24 | 0 | 54 | 27.0 |
| 9 | Bowling Green | 2 | 32 | 8 | 3 | 43 | 21.5 |
| 9 | Kent State | 3 | 32 | 41 | 2 | 75 | 25.0 |
| 11 | Northern Illinois | 2 | 34 | 16 | 3 | 53 | 26.5 |