2021 Mid-American Conference Leaders Opponent First Downs - Games Lost Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Central Michigan | 4 | 41 | 52 | 7 | 100 | 25.0 |
| 2 | Western Michigan | 5 | 53 | 39 | 6 | 98 | 19.6 |
| 2 | Toledo | 6 | 53 | 66 | 16 | 135 | 22.5 |
| 4 | Miami (Ohio) | 6 | 61 | 53 | 15 | 129 | 21.5 |
| 5 | Northern Illinois | 5 | 75 | 55 | 4 | 134 | 26.8 |
| 6 | Ball State | 7 | 83 | 69 | 10 | 162 | 23.1 |
| 6 | Eastern Michigan | 6 | 83 | 49 | 14 | 146 | 24.3 |
| 8 | Buffalo | 8 | 86 | 76 | 14 | 176 | 22.0 |
| 9 | Kent State | 7 | 94 | 81 | 15 | 190 | 27.1 |
| 10 | Bowling Green | 8 | 96 | 70 | 12 | 178 | 22.3 |
| 11 | Ohio | 9 | 102 | 95 | 20 | 217 | 24.1 |
| 12 | Akron | 10 | 149 | 93 | 12 | 254 | 25.4 |