2021 Mid-American Conference Leaders Scoring Defense - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 12 | 28 | 26 | 25 | 1 | 0 | 273 | 22.8 |
| 2 | Ohio | 11 | 40 | 18 | 34 | 2 | 2 | 336 | 30.5 |
| 3 | Central Michigan | 12 | 42 | 14 | 35 | 3 | 0 | 335 | 27.9 |
| 4 | Miami (Ohio) | 12 | 38 | 9 | 36 | 1 | 0 | 293 | 24.4 |
| 5 | Ball State | 12 | 41 | 19 | 37 | 2 | 2 | 348 | 29.0 |
| 6 | Western Michigan | 12 | 46 | 16 | 41 | 1 | 0 | 367 | 30.6 |
| 7 | Eastern Michigan | 12 | 48 | 14 | 43 | 1 | 0 | 375 | 31.3 |
| 7 | Bowling Green | 11 | 46 | 13 | 43 | 0 | 0 | 358 | 32.5 |
| 9 | Buffalo | 11 | 46 | 10 | 44 | 0 | 1 | 352 | 32.0 |
| 10 | Northern Illinois | 13 | 59 | 15 | 53 | 2 | 1 | 458 | 35.2 |
| 11 | Kent State | 13 | 64 | 18 | 56 | 1 | 1 | 498 | 38.3 |
| 12 | Akron | 11 | 60 | 13 | 57 | 1 | 1 | 460 | 41.8 |