2021 Mid-American Conference Leaders Scoring Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 12 | 25 | 26 | 23 | 0 | 0 | 251 | 20.9 |
| 2 | Ohio | 11 | 35 | 22 | 29 | 2 | 3 | 315 | 28.6 |
| 3 | Miami (Ohio) | 12 | 32 | 9 | 30 | 1 | 0 | 251 | 20.9 |
| 4 | Western Michigan | 11 | 34 | 14 | 31 | 1 | 0 | 279 | 25.4 |
| 5 | Central Michigan | 13 | 42 | 14 | 35 | 3 | 0 | 335 | 25.8 |
| 6 | Ball State | 13 | 44 | 19 | 40 | 2 | 2 | 369 | 28.4 |
| 7 | Eastern Michigan | 13 | 50 | 14 | 44 | 2 | 0 | 390 | 30.0 |
| 7 | Bowling Green | 12 | 47 | 14 | 44 | 0 | 0 | 368 | 30.7 |
| 9 | Buffalo | 12 | 47 | 10 | 45 | 0 | 1 | 359 | 29.9 |
| 10 | Northern Illinois | 13 | 52 | 15 | 46 | 2 | 1 | 409 | 31.5 |
| 11 | Akron | 11 | 54 | 12 | 51 | 1 | 1 | 415 | 37.7 |
| 12 | Kent State | 13 | 61 | 19 | 53 | 1 | 0 | 478 | 36.8 |