2021 Mid-American Conference Leaders Total Defense - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 6 | 865 | 906 | 415 | 1771 | 4.27 | 295.2 |
| 2 | Bowling Green | 5 | 835 | 1039 | 382 | 1874 | 4.91 | 374.8 |
| 3 | Kent State | 4 | 579 | 933 | 303 | 1512 | 4.99 | 378.0 |
| 4 | Western Michigan | 5 | 464 | 1065 | 301 | 1529 | 5.08 | 305.8 |
| 5 | Miami (Ohio) | 7 | 950 | 1724 | 478 | 2674 | 5.59 | 382.0 |
| 6 | Ball State | 2 | 275 | 519 | 141 | 794 | 5.63 | 397.0 |
| 7 | Ohio | 6 | 1208 | 1172 | 422 | 2380 | 5.64 | 396.7 |
| 8 | Central Michigan | 6 | 809 | 1734 | 414 | 2543 | 6.14 | 423.8 |
| 9 | Eastern Michigan | 5 | 916 | 1204 | 339 | 2120 | 6.25 | 424.0 |
| 10 | Northern Illinois | 6 | 1455 | 1199 | 417 | 2654 | 6.36 | 442.3 |
| 11 | Buffalo | 7 | 1427 | 1513 | 456 | 2940 | 6.45 | 420.0 |
| 12 | Akron | 7 | 1879 | 1373 | 458 | 3252 | 7.10 | 464.6 |