2021 Mid-American Conference Leaders Total Defense - All Games through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Toledo | 13 | 1969 | 2583 | 933 | 4552 | 4.88 | 350.2 |
| 2 | Bowling Green | 12 | 2254 | 2234 | 850 | 4488 | 5.28 | 374.0 |
| 3 | Miami (Ohio) | 13 | 1897 | 2893 | 865 | 4790 | 5.54 | 368.5 |
| 4 | Central Michigan | 13 | 1551 | 3422 | 889 | 4973 | 5.59 | 382.5 |
| 5 | Western Michigan | 13 | 1886 | 2423 | 741 | 4309 | 5.82 | 331.5 |
| 6 | Ball State | 13 | 2293 | 3110 | 926 | 5403 | 5.83 | 415.6 |
| 7 | Ohio | 12 | 2316 | 2871 | 865 | 5187 | 6.00 | 432.3 |
| 8 | Kent State | 14 | 2882 | 3724 | 1066 | 6606 | 6.20 | 471.9 |
| 9 | Eastern Michigan | 13 | 2599 | 3070 | 902 | 5669 | 6.28 | 436.1 |
| 10 | Buffalo | 12 | 2339 | 2651 | 787 | 4990 | 6.34 | 415.8 |
| 11 | Northern Illinois | 14 | 3003 | 3332 | 925 | 6335 | 6.85 | 452.5 |
| 12 | Akron | 12 | 2987 | 2622 | 783 | 5609 | 7.16 | 467.4 |