2021 Mid-American Conference Leaders Rushing Defense - When Winning By 15+ Pts through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Akron | 2 | 6 | -13 | -2.17 | 0 | 3 | 0 | 0 | 0 |
| 2 | Ohio | 3 | 27 | 70 | 2.59 | 1 | 10 | 5 | 1 | 0 |
| 2 | Bowling Green | 2 | 27 | 97 | 3.59 | 2 | 14 | 6 | 1 | 0 |
| 4 | Ball State | 5 | 35 | 112 | 3.20 | 1 | 25 | 10 | 4 | 1 |
| 5 | Northern Illinois | 4 | 47 | 223 | 4.74 | 1 | 26 | 12 | 9 | 3 |
| 6 | Miami (Ohio) | 4 | 66 | 233 | 3.53 | 0 | 26 | 14 | 9 | 1 |
| 7 | Central Michigan | 7 | 70 | 161 | 2.30 | 4 | 21 | 10 | 6 | 1 |
| 7 | Western Michigan | 5 | 70 | 202 | 2.89 | 4 | 44 | 13 | 12 | 4 |
| 9 | Buffalo | 3 | 74 | 198 | 2.68 | 3 | 42 | 13 | 9 | 3 |
| 10 | Eastern Michigan | 5 | 79 | 319 | 4.04 | 6 | 26 | 22 | 11 | 2 |
| 11 | Kent State | 5 | 93 | 383 | 4.12 | 5 | 32 | 24 | 13 | 4 |
| 12 | Toledo | 6 | 96 | 391 | 4.07 | 1 | 52 | 20 | 11 | 4 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||