2021 Mid-American Conference Leaders Long All Purpose Plays - Games at Home Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Keshunn Abram | Kent State | SR | WR | 5 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 1 | Justin Hall | Ball State | SR | WR | 5 | 6 | 3 | 1 | 1 | 1 | 1 | 1 |
| 1 | Bryant Koback | Toledo | JR | RB | 6 | 6 | 5 | 3 | 2 | 1 | 0 | 0 |
| 1 | Matt Landers | Toledo | JR | WR | 5 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 1 | Marion Lukes | CMU | FR | RB | 6 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |
| 1 | Devin Maddox | Toledo | SO | WR | 6 | 3 | 1 | 1 | 1 | 1 | 1 | 0 |
| 1 | Jonzell Norrils | Akron | FR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | Kalil Pimpleton | CMU | JR | WR | 6 | 5 | 2 | 1 | 1 | 1 | 0 | 0 |
| 1 | Clint Ratkovich | N Illinois | SR | RB | 6 | 2 | 2 | 2 | 1 | 1 | 1 | 1 |
| 1 | Trayvon Rudolph | N Illinois | FR | WR | 6 | 5 | 2 | 1 | 1 | 1 | 1 | 1 |
| 1 | Jack Sorenson | Miami (Oh) | SR | WR | 5 | 4 | 3 | 3 | 1 | 1 | 1 | 0 |
| 1 | Jacquez Stuart | Toledo | FR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 1 | De'Montre Tuggle | Ohio | SR | RB | 6 | 4 | 3 | 1 | 1 | 1 | 1 | 0 |
| 1 | Sean Tyler | W Mich | SO | RB | 6 | 5 | 2 | 2 | 2 | 1 | 1 | 1 |
| 1 | Harrison Waylee | N Illinois | FR | RB | 3 | 2 | 1 | 1 | 1 | 1 | 0 | 0 |
| 1 | Xavier Williams | Kent State | SR | RB | 5 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |