2021 Big Ten Conference Leaders Rushing Defense - Games in November Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Nebraska | 3 | 98 | 528 | 5.39 | 4 | 32.67 | 176.00 |
| 2 | Ohio State | 4 | 115 | 567 | 4.93 | 7 | 28.75 | 141.75 |
| 3 | Michigan State | 4 | 125 | 426 | 3.41 | 4 | 31.25 | 106.50 |
| 4 | Minnesota | 4 | 128 | 459 | 3.59 | 3 | 32.00 | 114.75 |
| 5 | Illinois | 3 | 135 | 379 | 2.81 | 4 | 45.00 | 126.33 |
| 6 | Wisconsin | 4 | 136 | 336 | 2.47 | 4 | 34.00 | 84.00 |
| 7 | Purdue | 4 | 140 | 646 | 4.61 | 7 | 35.00 | 161.50 |
| 8 | Northwestern | 4 | 143 | 720 | 5.03 | 9 | 35.75 | 180.00 |
| 9 | Maryland | 4 | 146 | 602 | 4.12 | 7 | 36.50 | 150.50 |
| 10 | Penn State | 4 | 147 | 460 | 3.13 | 3 | 36.75 | 115.00 |
| 11 | Iowa | 4 | 149 | 475 | 3.19 | 3 | 37.25 | 118.75 |
| 12 | Michigan | 4 | 151 | 461 | 3.05 | 3 | 37.75 | 115.25 |
| 13 | Indiana | 4 | 164 | 768 | 4.68 | 11 | 41.00 | 192.00 |
| 14 | Rutgers | 4 | 170 | 795 | 4.68 | 7 | 42.50 | 198.75 |