2021 Big Ten Conference Leaders Rushing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Wisconsin | 3 | 68 | 69 | 1.01 | 1 | 22.67 | 23.00 |
| 2 | Minnesota | 4 | 102 | 308 | 3.02 | 4 | 25.50 | 77.00 |
| 3 | Indiana | 4 | 114 | 434 | 3.81 | 6 | 28.50 | 108.50 |
| 4 | Maryland | 4 | 133 | 447 | 3.36 | 4 | 33.25 | 111.75 |
| 5 | Purdue | 4 | 135 | 487 | 3.61 | 4 | 33.75 | 121.75 |
| 6 | Rutgers | 4 | 138 | 451 | 3.27 | 5 | 34.50 | 112.75 |
| 7 | Michigan | 4 | 142 | 533 | 3.75 | 1 | 35.50 | 133.25 |
| 8 | Northwestern | 4 | 143 | 747 | 5.22 | 7 | 35.75 | 186.75 |
| 9 | Iowa | 4 | 147 | 339 | 2.31 | 2 | 36.75 | 84.75 |
| 10 | Penn State | 4 | 150 | 489 | 3.26 | 4 | 37.50 | 122.25 |
| 11 | Ohio State | 4 | 156 | 621 | 3.98 | 6 | 39.00 | 155.25 |
| 12 | Michigan State | 4 | 157 | 518 | 3.30 | 4 | 39.25 | 129.50 |
| 13 | Nebraska | 5 | 174 | 696 | 4.00 | 3 | 34.80 | 139.20 |
| 14 | Illinois | 5 | 175 | 679 | 3.88 | 7 | 35.00 | 135.80 |