2021 American Athletic Conference Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Tulsa | 2 | 196 | 652 | 148 | 848 | 5.73 | 424.0 |
| 2 | Houston | 2 | 192 | 457 | 140 | 649 | 4.64 | 324.5 |
| 3 | UCF | 2 | 500 | 352 | 139 | 852 | 6.13 | 426.0 |
| 4 | South Florida | 2 | 213 | 355 | 136 | 568 | 4.18 | 284.0 |
| 5 | Tulane | 2 | 239 | 462 | 133 | 701 | 5.27 | 350.5 |
| 6 | Cincinnati | 2 | 192 | 354 | 130 | 546 | 4.20 | 273.0 |
| 7 | Temple | 2 | 191 | 309 | 123 | 500 | 4.07 | 250.0 |
| 8 | SMU | 1 | 350 | 245 | 80 | 595 | 7.44 | 595.0 |
| 9 | East Carolina | 1 | 116 | 152 | 63 | 268 | 4.25 | 268.0 |
| 10 | Memphis | 1 | 87 | 159 | 53 | 246 | 4.64 | 246.0 |