2021 American Athletic Conference Leaders First Downs - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Memphis | 7 | 41 | 88 | 21 | 150 | 21.4 |
| 2 | South Florida | 8 | 62 | 79 | 13 | 154 | 19.3 |
| 3 | Tulane | 9 | 64 | 78 | 16 | 158 | 17.6 |
| 4 | Cincinnati | 8 | 68 | 77 | 10 | 155 | 19.4 |
| 5 | East Carolina | 6 | 37 | 67 | 13 | 117 | 19.5 |
| 6 | Houston | 5 | 30 | 59 | 9 | 98 | 19.6 |
| 7 | SMU | 4 | 33 | 51 | 8 | 92 | 23.0 |
| 7 | Tulsa | 5 | 39 | 51 | 15 | 105 | 21.0 |
| 9 | UCF | 4 | 31 | 37 | 7 | 75 | 18.8 |
| 10 | Temple | 5 | 30 | 32 | 6 | 68 | 13.6 |
| 11 | Navy | 10 | 128 | 22 | 13 | 163 | 16.3 |