2021 American Athletic Conference Leaders First Downs - All Games through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Houston | 14 | 98 | 182 | 23 | 303 | 21.6 |
| 2 | SMU | 12 | 116 | 165 | 18 | 299 | 24.9 |
| 3 | Memphis | 12 | 89 | 150 | 31 | 270 | 22.5 |
| 4 | East Carolina | 12 | 102 | 141 | 21 | 264 | 22.0 |
| 4 | Cincinnati | 14 | 122 | 141 | 15 | 278 | 19.9 |
| 6 | Tulsa | 13 | 126 | 138 | 30 | 294 | 22.6 |
| 7 | UCF | 13 | 122 | 121 | 19 | 262 | 20.2 |
| 8 | Tulane | 12 | 106 | 110 | 18 | 234 | 19.5 |
| 9 | South Florida | 12 | 120 | 107 | 17 | 244 | 20.3 |
| 10 | Temple | 12 | 72 | 89 | 16 | 177 | 14.8 |
| 11 | Navy | 12 | 160 | 27 | 15 | 202 | 16.8 |