2021 American Athletic Conference Leaders Total Offense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UCF | 5 | 1325 | 1308 | 377 | 2633 | 6.98 | 526.6 |
| 2 | Tulsa | 5 | 995 | 1494 | 383 | 2489 | 6.50 | 497.8 |
| 3 | SMU | 4 | 929 | 1270 | 305 | 2199 | 7.21 | 549.8 |
| 4 | Houston | 5 | 649 | 1287 | 347 | 1936 | 5.58 | 387.2 |
| 5 | Memphis | 4 | 750 | 1170 | 265 | 1920 | 7.25 | 480.0 |
| 6 | Cincinnati | 5 | 662 | 1207 | 306 | 1869 | 6.11 | 373.8 |
| 7 | Tulane | 4 | 623 | 1057 | 294 | 1680 | 5.71 | 420.0 |
| 8 | East Carolina | 4 | 518 | 1080 | 278 | 1598 | 5.75 | 399.5 |
| 9 | Temple | 4 | 483 | 856 | 242 | 1339 | 5.53 | 334.8 |
| 10 | South Florida | 4 | 632 | 704 | 280 | 1336 | 4.77 | 334.0 |
| 11 | Navy | 4 | 735 | 193 | 252 | 928 | 3.68 | 232.0 |