2021 American Athletic Conference Leaders First Downs - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Memphis | 8 | 55 | 109 | 22 | 186 | 23.3 |
| 2 | Tulsa | 8 | 76 | 76 | 19 | 171 | 21.4 |
| 3 | Houston | 9 | 64 | 121 | 15 | 200 | 22.2 |
| 4 | East Carolina | 8 | 80 | 97 | 14 | 191 | 23.9 |
| 5 | SMU | 8 | 67 | 111 | 13 | 191 | 23.9 |
| 6 | Navy | 8 | 118 | 18 | 12 | 148 | 18.5 |
| 7 | South Florida | 8 | 82 | 76 | 10 | 168 | 21.0 |
| 7 | UCF | 8 | 59 | 60 | 10 | 129 | 16.1 |
| 9 | Temple | 8 | 45 | 57 | 9 | 111 | 13.9 |
| 10 | Tulane | 8 | 67 | 65 | 8 | 140 | 17.5 |
| 11 | Cincinnati | 9 | 81 | 96 | 7 | 184 | 20.4 |