2021 American Athletic Conference Leaders Total Offense - All Games through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 14 | 1992 | 3802 | 973 | 5794 | 5.95 | 413.9 |
| 2 | SMU | 12 | 1937 | 3654 | 890 | 5591 | 6.28 | 465.9 |
| 3 | Memphis | 12 | 1645 | 3585 | 861 | 5230 | 6.07 | 435.8 |
| 4 | Cincinnati | 14 | 2417 | 3377 | 863 | 5794 | 6.71 | 413.9 |
| 5 | East Carolina | 12 | 1945 | 3253 | 899 | 5198 | 5.78 | 433.2 |
| 6 | Tulsa | 13 | 2496 | 3244 | 960 | 5740 | 5.98 | 441.5 |
| 7 | UCF | 13 | 2552 | 2680 | 866 | 5232 | 6.04 | 402.5 |
| 8 | Tulane | 12 | 1977 | 2661 | 823 | 4638 | 5.64 | 386.5 |
| 9 | South Florida | 12 | 1902 | 2309 | 841 | 4211 | 5.01 | 350.9 |
| 10 | Temple | 12 | 1315 | 2126 | 724 | 3441 | 4.75 | 286.8 |
| 11 | Navy | 12 | 2717 | 681 | 794 | 3398 | 4.28 | 283.2 |