2021 American Athletic Conference Leaders Rushing Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Houston | 11 | 354 | 1192 | 3.37 | 10 | 32.18 | 108.36 |
| 2 | Navy | 12 | 390 | 1572 | 4.03 | 25 | 32.50 | 131.00 |
| 3 | East Carolina | 10 | 334 | 1710 | 5.12 | 18 | 33.40 | 171.00 |
| 4 | Tulsa | 10 | 349 | 1310 | 3.75 | 15 | 34.90 | 131.00 |
| 5 | USF | 9 | 316 | 1699 | 5.38 | 20 | 35.11 | 188.78 |
| 6 | SMU | 10 | 380 | 1362 | 3.58 | 14 | 38.00 | 136.20 |
| 7 | Tulane | 9 | 355 | 1369 | 3.86 | 16 | 39.44 | 152.11 |
| 8 | UCF | 10 | 398 | 1650 | 4.15 | 19 | 39.80 | 165.00 |
| 9 | Cincinnati | 11 | 462 | 1542 | 3.34 | 12 | 42.00 | 140.18 |
| 10 | Memphis | 10 | 445 | 1856 | 4.17 | 20 | 44.50 | 185.60 |
| 11 | Temple | 9 | 418 | 2124 | 5.08 | 23 | 46.44 | 236.00 |