2021 American Athletic Conference Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UCF | 5 | 142 | 577 | 4.06 | 8 | 28.40 | 115.40 |
| 2 | Houston | 5 | 159 | 531 | 3.34 | 3 | 31.80 | 106.20 |
| 3 | SMU | 4 | 129 | 546 | 4.23 | 2 | 32.25 | 136.50 |
| 4 | Memphis | 4 | 138 | 452 | 3.28 | 6 | 34.50 | 113.00 |
| 4 | South Florida | 4 | 138 | 931 | 6.75 | 10 | 34.50 | 232.75 |
| 6 | Tulsa | 5 | 175 | 663 | 3.79 | 5 | 35.00 | 132.60 |
| 7 | East Carolina | 4 | 150 | 670 | 4.47 | 8 | 37.50 | 167.50 |
| 8 | Navy | 4 | 153 | 551 | 3.60 | 13 | 38.25 | 137.75 |
| 9 | Cincinnati | 5 | 194 | 799 | 4.12 | 4 | 38.80 | 159.80 |
| 10 | Tulane | 4 | 177 | 725 | 4.10 | 10 | 44.25 | 181.25 |
| 11 | Temple | 4 | 180 | 693 | 3.85 | 11 | 45.00 | 173.25 |