2021 American Athletic Conference Leaders Tackles For Loss Allowed - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | University of Memphis | 1 | 3.0 | 5 | 3.00 |
| 2 | Southern Methodist University | 1 | 4.0 | 8 | 4.00 |
| 3 | East Carolina University | 1 | 8.0 | 44 | 8.00 |
| 4 | University of South Florida | 2 | 14.0 | 46 | 7.00 |
| 4 | Temple University | 2 | 15.0 | 46 | 7.50 |
| 6 | Tulane University | 2 | 13.0 | 49 | 6.50 |
| 7 | The University of Tulsa | 2 | 12.0 | 60 | 6.00 |
| 8 | University of Houston | 2 | 15.0 | 64 | 7.50 |
| 9 | University of Central Florida | 2 | 16.0 | 68 | 8.00 |
| 10 | University of Cincinnati | 2 | 13.0 | 86 | 6.50 |