2021 American Athletic Conference Leaders Opponent First Downs - Games in October Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Houston | 4 | 17 | 40 | 10 | 67 | 16.8 |
| 2 | East Carolina | 4 | 28 | 38 | 4 | 70 | 17.5 |
| 3 | SMU | 4 | 29 | 38 | 5 | 72 | 18.0 |
| 4 | Tulsa | 4 | 33 | 42 | 9 | 84 | 21.0 |
| 4 | Tulane | 4 | 33 | 56 | 3 | 92 | 23.0 |
| 6 | Navy | 5 | 34 | 41 | 6 | 81 | 16.2 |
| 7 | Cincinnati | 5 | 38 | 39 | 9 | 86 | 17.2 |
| 8 | South Florida | 4 | 44 | 49 | 6 | 99 | 24.8 |
| 9 | Memphis | 4 | 46 | 28 | 4 | 78 | 19.5 |
| 10 | UCF | 5 | 60 | 36 | 13 | 109 | 21.8 |
| 10 | Temple | 4 | 60 | 42 | 5 | 107 | 26.8 |