2021 American Athletic Conference Leaders Opponent First Downs - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Navy | 8 | 53 | 73 | 10 | 136 | 17.0 |
| 1 | Houston | 9 | 53 | 81 | 20 | 154 | 17.1 |
| 3 | SMU | 8 | 56 | 88 | 14 | 158 | 19.8 |
| 4 | East Carolina | 8 | 61 | 65 | 8 | 134 | 16.8 |
| 4 | Tulsa | 8 | 61 | 78 | 16 | 155 | 19.4 |
| 6 | Tulane | 8 | 65 | 95 | 8 | 168 | 21.0 |
| 7 | South Florida | 8 | 80 | 100 | 10 | 190 | 23.8 |
| 8 | Cincinnati | 9 | 82 | 70 | 18 | 170 | 18.9 |
| 9 | UCF | 8 | 83 | 79 | 17 | 179 | 22.4 |
| 10 | Memphis | 8 | 95 | 74 | 7 | 176 | 22.0 |
| 11 | Temple | 8 | 105 | 83 | 11 | 199 | 24.9 |