2021 American Athletic Conference Leaders Rushing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UCF | 3 | 77 | 235 | 3.05 | 4 | 25.67 | 78.33 |
| 2 | Cincinnati | 3 | 119 | 414 | 3.48 | 3 | 39.67 | 138.00 |
| 3 | Navy | 3 | 120 | 404 | 3.37 | 11 | 40.00 | 134.67 |
| 4 | SMU | 4 | 129 | 546 | 4.23 | 2 | 32.25 | 136.50 |
| 5 | Memphis | 4 | 138 | 452 | 3.28 | 6 | 34.50 | 113.00 |
| 5 | South Florida | 4 | 138 | 931 | 6.75 | 10 | 34.50 | 232.75 |
| 7 | East Carolina | 4 | 150 | 670 | 4.47 | 8 | 37.50 | 167.50 |
| 8 | Houston | 4 | 153 | 526 | 3.44 | 5 | 38.25 | 131.50 |
| 9 | Tulsa | 4 | 156 | 592 | 3.79 | 4 | 39.00 | 148.00 |
| 10 | Tulane | 4 | 177 | 725 | 4.10 | 10 | 44.25 | 181.25 |
| 11 | Temple | 4 | 180 | 693 | 3.85 | 11 | 45.00 | 173.25 |