2021 American Athletic Conference Leaders Rushing Defense - All Games through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 12 | 390 | 1572 | 4.03 | 25 | 32.50 | 131.00 |
| 2 | East Carolina | 12 | 412 | 1940 | 4.71 | 20 | 34.33 | 161.67 |
| 3 | South Florida | 12 | 429 | 2487 | 5.80 | 28 | 35.75 | 207.25 |
| 4 | SMU | 12 | 438 | 1651 | 3.77 | 15 | 36.50 | 137.58 |
| 5 | Houston | 14 | 445 | 1515 | 3.40 | 13 | 31.79 | 108.21 |
| 6 | Tulsa | 13 | 479 | 1857 | 3.88 | 19 | 36.85 | 142.85 |
| 6 | UCF | 13 | 479 | 2070 | 4.32 | 24 | 36.85 | 159.23 |
| 8 | Tulane | 12 | 484 | 1901 | 3.93 | 25 | 40.33 | 158.42 |
| 9 | Memphis | 12 | 489 | 2005 | 4.10 | 22 | 40.75 | 167.08 |
| 10 | Temple | 12 | 555 | 2646 | 4.77 | 33 | 46.25 | 220.50 |
| 11 | Cincinnati | 14 | 583 | 2088 | 3.58 | 14 | 41.64 | 149.14 |