2021 American Athletic Conference Leaders Scoring Defense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | University of Houston | 13 | 31 | 11 | 28 | 2 | 0 | 251 | 19.3 |
| 1 | University of Central Florida | 12 | 32 | 13 | 32 | 0 | 0 | 263 | 21.9 |
| 1 | The University of Tulsa | 9 | 23 | 14 | 20 | 2 | 0 | 204 | 22.7 |
| 1 | East Carolina University | 10 | 32 | 9 | 26 | 2 | 0 | 249 | 24.9 |
| 1 | Southern Methodist University | 10 | 32 | 10 | 27 | 0 | 0 | 249 | 24.9 |
| 1 | University of Memphis | 11 | 40 | 14 | 36 | 1 | 0 | 320 | 29.1 |
| 1 | Tulane University | 8 | 31 | 7 | 29 | 0 | 0 | 236 | 29.5 |
| 1 | University of South Florida | 8 | 31 | 8 | 27 | 0 | 0 | 237 | 29.6 |
| 9 | University of Cincinnati | 11 | 21 | 9 | 19 | 1 | 1 | 176 | 16.0 |
| 9 | U.S. Naval Academy | 9 | 32 | 8 | 30 | 1 | 1 | 250 | 27.8 |
| 9 | Temple University | 10 | 47 | 10 | 45 | 1 | 1 | 361 | 36.1 |